We believe in the transformative power of synthetic biology as a mean to build a sustainable and resilient society which meets the needs of local communities. We envision a future where synthetic biology enables local economies of knowledge rather than a global economy of scale. We want to build a future where bio-based distributed manufacturing enables sustainable local value chains connected globally. For this vision to become true, designing biology shall become affordable, shareable, and reliable tool accessible globally.

Our mission is to accelerate innovation in synthetic biology by ensuring maintenance and access to biological information.

We have built a FAIR-compliant digital and physical repository of biological information designed to accelerate innovation in synthetic biology by ensuring access to critical data.

 

1. A platform to support innovation and sustainable economies
A community-curated digital repository of sequences and relatated data to accelerate R&D. Our catalogue of biological parts (biomodules) and full-lenght plasmids (constructs) comprises sequences and related information validated by authors and peers, with cross-references to publications and external databases. Each Doulix user may choose to make her sequences public and available for the entire community. In addition, each user may choose to deposit a physical sample of her constructs at Doulix for distibution worldwide. Public Biomodules and Constructs can be sourced directly through Doulix and delivered lyophilized worlwide. Finally, individual researchers supported by EU funds can also access our DNA synthesis service at a reduced price as part of collaboration with the EU Horizon 2020 research and innovation programme to make DNA synthesis affordable and reliable for European consortia.

2. Standards for data and experiments
A lot of resources get typically wasted in retrieving information from multiple and heterogeneous sources. Doulix links data to biomodules following strict and unique standards to offer a uniform platform easily accessible by users, designed to improve the time and quality of their analysis.

3. A platform to grow and educate
We aim at rising the tide for all boats. Together with leading universities we organize both remote and on-premise workshop to promote the synthetic biology design framework and the adoption of quality standards to allow an effective and timely sharing of data.

We wouldn’t have gone this far without our network of partnerships that helped to shape and to improve DOULIX. 

We would like to thank our academic and private partners for the valuable feedback over the years.

THE GRAIL project, Funded by the EU with grant nr. 278557, aims at designing protein-based bioactive scaffold that locally regenerates intima growth after endovascular treatment of the obstructed arteries in patients with atherosclerosis.
The set of sequences that build the foundations of THE GRAIL was the first seed of what would later become the DOULIX’s core infrastructure. We would like to thank Bioforge Lab at University of Valladolid and Technical Protein Nanobiotechnology for their support.

There is always a turning point, for us it was the NEXT project.

The NEXT project, funded by the EU with grant nr. 602235, aims at developing the next generation of chimeric pancreatic islet for diabetes 1 treatment.
One of the pillars of NEXT is the design of modular proteins endowed with multiple biological functions such as immune-modulation and angiogenesis.

The challenge posed by the design of NEXT modular proteins was the spark that triggered everything, we developed the DNAmate assembling technique (DNA modular assembling technology) and the DOULIX’s assembler.

We never rest still and we always look for improvements, we are happy to team up with the LIAR consortium, a project funded by the EU with grant nr. 686585, to develop the next sequence editor for synthetic biology.

We would like to thank the Laboratory for Artificial Biology of the University of Trento and the Environmental Microbiology group of the Spanish National Research Council for their help in design DOULIX’s designer.